Blogpost - JASE - Page 9

Melatonin – It Isn’t Just for Sleep

Part one focuses on what melatonin is, part two will discuss how melatonin plays a role in winter blues or seasonal affective disorder, along with tips to navigate this time of year.

What is melatonin?

You may have heard that melatonin is a hormone that regulates sleep. You may have even heard that melatonin is a powerful antioxidant. Melatonin is both and a lot more.

There are two places melatonin is synthesized and both work in vastly different capacities.

One is subcellular melatonin and the other is circulating melatonin.

Subcellular melatonin is known as the “hormone of daylight” It is synthesized in the mitochondria of  cells throughout the body– skin, epithelial, liver, thyroid, kidney, gastrointestinal tract, bone marrow, leukocytes, immune cells and many others. Once manufactured the melatonin stays near the cells and does its work. Stimulated by the UV spectrum of sunlight, or viruses, free radicals are neutralized by the antioxidant response of melatonin. Melatonin also stimulates other antioxidant enzymes to help fight free radicals.

There is some evidence that subcellular melatonin is synthesized by exposure of near infrared light (NIR).

Circulating Melatonin

Circulating melatonin is known as the “hormone of darkness”. It is produced in the pineal gland and regulated by the suprachiasmatic nucleus (SCN) Melatonin secretion is stimulated by darkness and inhibited by light, and in coordination with the (SCN), it is involved in maintaining circadian rhythmicity and regulating sleep. The SCN regulates the timing of melatonin release in a feedback loop, whereby melatonin levels determine the SCN regulation.

 Circadian rhythm disruption is proven to be one of the contributing factors in cancer progression and development.  Blue light, such as LED and computer monitors suppress melatonin production, leading to altered circadian rhythm.

 Circadian rhythm disruption is proven to be one of the contributing factors in cancer progression and development.  Blue light, such as LED and computer monitors suppress melatonin production, leading to altered circadian rhythm.

How to benefit from subcellular and circulating melatonin

Before bedtime:

  1. Avoid stimulating lights- blue light from computer and phone screens, LED lights- these will shut down circulating melatonin and disrupt circadian rhythm. Incandescent light to read by are a good choice. Reading on a pad even with blue blocker can disrupt melatonin levels. The blue blockers installed on many devices are not adequate to block the light.
  2. Campfires, candles, and red lights help keep melatonin levels intact and may even stimulate the subcellular melatonin to go after free radicals.
  3. Practice sleep hygiene- Go to bed at set time, have a routine. This helps signal your body that its time to go to bed. In addition, avoid stimulating conversations, snacking before bed and exercise a few hours before bedtime.
  4. Have your vitamin D level checked. Vitamin D plays an important part of melatonin regulation.
  5. Even though there isn’t clear cut evidence that blue light blocking glasses work, a small study revealed sleep duration and nighttime melatonin levels increased after use of blue light blocking glasses.

Our lives have become increasingly distant from natural light. Our sleep wake cycles are constantly disrupted by our modern way of living.

Chronobiology, the study of circadian rhythms and our health is becoming an increasingly important field of study.  How light affects melatonin levels is one area that chronobiology focuses on.

- Brooke Lounsbury

Medical Content Writer

Lifesaving Medications

Everyone should be empowered to care for themselves and their loved ones during the unexpected.

Recent Posts

Keeping you informed and safe.

How Long do My Meds Last? A Look at Metronidazole

How Long do My Meds Last? A Look at Metronidazole

What is metronidazole? Metronidazole is an antibiotic that is used to treat bacterial infections of the vagina, stomach, liver, skin, joints, brain and spinal cord, lungs, heart, or bloodstream. In 2020, it was the 222nd most commonly prescribed medication in the...

Pharmacy Techs Report Massive Drug Shortages

Pharmacy Techs Report Massive Drug Shortages

A highly concerning survey conducted by the Pharmacy Technician Certification Board, who grants a Supply Chain and Inventory Management for certification, has stated that nearly 96% of respondents report the pharmacy they work for faces drug shortages. Established in...

Join Our Newsletter

Our mission is to help you be more medically prepared. Join our newsletter and follow us on social media for health and safety tips each week!

Fentanyl Crisis: Do You Have Narcan?

The heartbreaking headlines of innocent lives touched by the accidental overdose of one of the most insidious drugs in our time continues to explode to never heard numbers.

A toddler almost died while playing at a Tacoma Park. He had accidentally been exposed to fentanyl while playing at the park, He was rushed to the ER where Narcan an opioid overdose reversal drug was administered.

A toddler playing in a San Francisco public park almost died after somehow being exposed to the opioid fentanyl. He was also given Narcan.

Infant son of tech boss overdoses on fentanyl found at San Francisco playground. EMT administered Narcan, bringing him back from the brink of death.

Teen dies from  fentanyl overdose. The video reveals that other teens had been given prescription meds laced with fentanyl. They weren’t aware of the fentanyl contamination.

Parents warn of fentanyl danger from fake pills after Rocklin teen’s heartbreaking death. He thought he was buying Percocet on the street. It was fentanyl. His family reveals SnapChat is being used by drug dealers to sell illegal drugs. Their son had used this to purchase the fentanyl.

There are so many stories I can’t possibly link all of them.

Other drugs, including prescription drugs are now being laced with fentanyl. It is impossible to tell if the drug has been tainted. It takes a small amount of fentanyl to contaminate a pill.

Note: Fentanyl is used legally in patches for extreme pain. It is 100 times more potent than morphine. These patches are highly regulated and are not the topic of this paper.

What is Narcan, AKA naloxone?

According to the CDC:

“Naloxone is a life-saving medication that can reverse an overdose from opioids—including heroin, fentanyl, and prescription opioid medications—when given in time.1 Naloxone is easy to use and small to carry. There are two forms of naloxone that anyone can use without medical training or authorization: prefilled nasal spray and injectable.”

Naloxone quickly reverses an overdose by blocking the effects of opioids. It can restore normal breathing within 2 to 3 minutes2 in a person whose breath has slowed, or even stopped, as a result of opioid overdose. More than one dose of naloxone may be required when stronger opioids like fentanyl are involved.

Naloxone won’t harm someone if they’re overdosing on drugs other than opioids, so it’s always best to use it if you think someone is overdosing.

Signs of overdose

Recognizing the signs of opioid overdose can save a life. Here are some things to look for:

  • Small, constricted “pinpoint pupils”
  • Falling asleep or losing consciousness
  • Slow, weak, or no breathing
  • Choking or gurgling sounds
  • Limp body
  • Cold and/or clammy skin
  • Discolored skin (especially in lips and nails)

What to do if you think someone is overdosing (from CDC website)

It may be hard to tell whether a person is high or experiencing an overdose. If you aren’t sure, treat it like an overdose—you could save a life.

  1. Call 911 Immediately.
  2. Administer naloxone, if available.
  3. Try to keep the person awake and breathing.
  4. Stay with the person until help arrives

Narcan, AKA Naloxone is legal in all 50 states Each state has its guidelines to obtain this lifesaving drug. I recently went online and ordered Narcan through the state of Washington portal. It was quick, easy and free. They even have a video on how to use and administer the Narcan.  I plan on keeping it in my car. My husband is doing the same.

Vending machines carrying Narcan

Vending machines are popping up across the country. However, they are few and widespread.

Across the U.S., cities including San Diego, Las Vegas and New York are installing vending machines and locker kiosks stocked with nasal sprays that contain naloxone, a medication that can be used in emergencies for someone who has overdosed on opioids, including fentanyl.

Good Samaritan laws are in place in most states to protect those who are overdosing and anyone assisting them in an emergency from arrest, charges, or a combination of these. Learn about the laws in your state.

Please google your states requirements for how to obtain Narcan. Some states keep the Narcan behind the counter at pharmacies, you just have to ask for it. Other states have mail order such as Washington state.

The stigma of having this lifesaving drug needs to go away. Too many people are being affected by this. Innocent little ones, unsuspecting teens and others are all becoming victims of this horrible drug.

- Brooke Lounsbury

Medical Content Writer

Lifesaving Medications

Everyone should be empowered to care for themselves and their loved ones during the unexpected.

Recent Posts

Keeping you informed and safe.

How Long do My Meds Last? A Look at Metronidazole

How Long do My Meds Last? A Look at Metronidazole

What is metronidazole? Metronidazole is an antibiotic that is used to treat bacterial infections of the vagina, stomach, liver, skin, joints, brain and spinal cord, lungs, heart, or bloodstream. In 2020, it was the 222nd most commonly prescribed medication in the...

Pharmacy Techs Report Massive Drug Shortages

Pharmacy Techs Report Massive Drug Shortages

A highly concerning survey conducted by the Pharmacy Technician Certification Board, who grants a Supply Chain and Inventory Management for certification, has stated that nearly 96% of respondents report the pharmacy they work for faces drug shortages. Established in...

Practice Gratitude – Improve Health

“I awoke this morning with devout thanksgiving for my friends, the old and the new.”

Ralph Waldo Emerson

Gratitude- The state of being grateful. Thankfulness Thanksgiving. Embracing and being grateful for what we have (the gift) and for the source (the giver) of it. The gift can come from another, a higher power or nature. 

The world is in upheaval. There are challenges facing all of us as we bid 2022 goodbye and welcome 2023 with a little trepidation. We are entering uncharted territory in world history. The good news is that we are not alone. How we enter this new year depends a lot on our attitude and ability to remain flexible to our changing landscape. In other words, our attitude can make or break us. Let’s take the higher road and focus on solutions.

Robert Emmons, professor of psychology at the University of California, Davis, is one of the world’s leading experts on the science of gratitude, conducted a series of tests to determine if acknowledging and expressing gratitude had any lasting health effects. After conducting several studies ranging from weekly to daily gratitude journaling, he concluded that daily expressions of gratitude had lasting positive outcomes physically, emotionally, and mentally. In other words, daily expressions of gratitude set the stage for continued habits of positive emotions and resilience. 

Practicing gratitude, either in written or spoken form activates the parasympathetic nervous system, which is known as the calming part of the nervous system. This in turn lowers cortisol levels and promotes feelings of wellbeing. 

Health benefits of practicing gratitude

  • Reduces stress- Stress hormones such as cortisol 23% lower
  • Lowers inflammation with reduced stress comes reduced inflammation
  • Improved heart health- lower blood pressure
  • Alleviates anxiety
  • Promotes social wellness
  • More likely to choose healthy habits such as diet and exercise
  • Better sleep quality
  • Higher sense of self worth
  • Improved immune function

Is gratefulness a personality trait or can it be learned?

While there are certain personalities that are naturally geared to be more grateful, gratitude can be developed into lifelong habits. Dr. Emmons believes you can cultivate gratitude. In this excellent video, he explains how to become more grateful.  (He has a whole series on gratitude on You Tube worth watching)  

How to practice gratitude

Practicing gratitude not only elevates another person but also elevates you. Dr Emmons work revealed daily and consistent focus on gratitude and being thankful had lasting benefits

The following are a few tips to get started:

    • Journal- Keep a daily journal of 5 things you are grateful for, commit to doing this daily for one month
  • Write letters to loved ones and those you appreciate. Let them know how you feel. It always feels good to get something in the mail that isn’t an advertisement or bill! This could be in combination with other forms of gratitude.
  • Tell 5 people something about them you are grateful for 
  • Text 5 people something positive. Let them know you are thinking about them
  • Start a couple’s journal. Leave it out on coffee table. Write something positive in it daily to each other. 
  • Take time out each day to meditate or pray. Focus on what is good in your life, and work towards solutions to challenges in your life.

Gratitude Quotes- to inspire you!

  1. “This is a wonderful day. I have never seen this one before.” Maya Angelou
  2. “When we focus on our gratitude, the tide of disappointment goes out and the tide of love rushes in.” Kristin Armstrong
  3. “When eating fruit, remember the one who planted the tree.” Vietnamese proverb
  4. “When I started counting my blessings, my whole life turned around.” Willie Nelson
  5. “Enjoy the little things, for one day you may look back and realize they were the big things.” Roert Brault
  6. “‘Enough’ is a feast.” Buddhist Proverb
  7. “He is a wise man who does not grieve for the things which he has not, but rejoices for those which he has.” Epictetus
  8. “Piglet noticed that even though he had a Very Small Heart, it could hold a rather large amount of Gratitude.” A.A. Milne
  9. “We must find time to stop and thank the people who make a difference in our lives.” John F. Kennedy
  10. “Gratitude is the ability to experience life as a gift. It liberates us from the prison of self-preoccupation.” John Ortberg
  11. “O Lord that lends me life, lend me a heart replete with thankfulness.” William Shakespeare
  12. “We can only be said to be alive in those moments when our hearts are conscious of our treasures.” Thornton Wilder

 

 

- Brooke Lounsbury

Medical Content Writer

Lifesaving Medications

Everyone should be empowered to care for themselves and their loved ones during the unexpected.

Recent Posts

Keeping you informed and safe.

How Long do My Meds Last? A Look at Metronidazole

How Long do My Meds Last? A Look at Metronidazole

What is metronidazole? Metronidazole is an antibiotic that is used to treat bacterial infections of the vagina, stomach, liver, skin, joints, brain and spinal cord, lungs, heart, or bloodstream. In 2020, it was the 222nd most commonly prescribed medication in the...

Pharmacy Techs Report Massive Drug Shortages

Pharmacy Techs Report Massive Drug Shortages

A highly concerning survey conducted by the Pharmacy Technician Certification Board, who grants a Supply Chain and Inventory Management for certification, has stated that nearly 96% of respondents report the pharmacy they work for faces drug shortages. Established in...

Avian Influenza Adds to Skyrocketing Thanksgiving Meal

Turkey jumps 73% in price over last year

Thanksgiving is a time for families and loved ones to get together and share a meal and give thanks- a longstanding tradition in many households across the U.S. The centerpiece for many of these meals is the turkey. Recent outbreaks of avian influenza has put a dent in available turkeys, sending the price to skyrocket. Over the past year over 6 million turkeys had to be culled due to highly pathogenic avian influenza(HPAI). This resulted in 2.5 percent reduction in turkeys going to market, however the USDA projects the numbers should rebound to pre cull (kill) numbers within a short time.  The CDC has an interactive map reveals where outbreaks are occurring in real time in both commercial and home flocks for each state and county.

Wholesale prices for frozen whole turkey hens: 

  • 2019 average: $0.89 per pound
  • 2020 average: $1.07 per pound
  • 2021 average: $1.23 per pound
  • 2022 average: $1.69 per pound (73% increase over 2021)

Avian flu not the only reason Thanksgiving will be more expensive. Exploding feed prices and energy prices are also contributing to a much more expensive thanksgiving meal. Aceoss the board food prices have risen  Farm Bureau projects that  Thanksgiving dinner will be 14% higher than 2021.

Domestic pets at risk

Bird flu is spread primarily through migratory waterfowl as they travel to their destinations. Bird droppings and sick or dead birds infected with the bird flu can infect pets if consumed or have prolonged contact with an infected bird. It is highly unlikely (but not impossible) for humans to come down with bird flu if you follow these precautions:

Watch for signs of illness in your pet

If your pet shows signs of illness that are indicative of bird flu:

  • Sudden death with no prior signs
  • Low energy or appetite
  • Purple discoloration or swelling of various body parts
  • Reduced egg production, or soft-shelled/misshapen eggs
  • Nasal discharge, coughing, or sneezing
  • Lack of coordination
  • Diarrhea

Don’t touch sick or dead birds, their feces or litter, or any surface or water source (ponds, waterers, buckets, pans, troughs) that might be contaminated with their saliva, feces, or any other bodily fluids without wearing personal protective equipment (PPE).

What to do if you find a dead or sick bird

If you find a dead bird, don’t touch it with your bare hands. Use a plastic bag or gloved hands and place it in garbage can and dispose of it in your garbage. To report unusual signs in birds you have seen in the wild, call 1-866-536-7593.

Can you get avian flu from eating infected turkey?

Bird flu virus can be passed through bird droppings and saliva on surfaces such as cages, tractors, and other farm equipment. Most people don’t need to worry about getting sick with bird flu virus. You cannot get bird flu from eating fully cooked chicken, turkey, or duck, because heat kills the virus.

Avian flu food safety

Proper food handling will prevent not only avian flu but foodborne illnesses such as E coli and Salmonella (The Jase case contains antibiotics that can handle Salmonella if the need arises) from contaminating you and your cooked food.

USDA Questions and Answers: Food Safety and Avian Influenza

(Excerpts from USDA pdf on avian flu and food safety)

  1. Can I get avian influenza from eating poultry or eggs?
  2. No. Poultry and eggs that are properly prepared and cooked are safe to eat. Proper food

safety practices are important every day. In addition to proper processing, proper handling and

cooking of poultry provides protection from viruses and bacteria, including avian influenza. As

we remind consumers each and everyday, there are four basic food safety steps to follow:

CLEAN, SEPARATE, COOK, and CHILL.

  1. Does proper food handling prevent avian influenza?
  2. Avian influenza is not transmissible by eating properly prepared poultry, so properly

prepared and cooked poultry and eggs are safe to eat. The chance of infected poultry or eggs

entering the food chain is extremely low because of the rapid onset of symptoms in poultry as

well as the safeguards USDA has in place, which include testing of flocks, and Federal

inspection programs.

  1. What does proper food handling mean?
  2. Proper handling and cooking of poultry provides protection against all avian influenza

viruses, as it does against other viruses and bacteria, including Salmonella and E.coli. Safe food

handling and preparation are important at all times. USDA continually reminds consumers to

practice safe food handling and preparation every day.

Cooking poultry, eggs, and other poultry products to the proper temperature and preventing

cross-contamination between raw and cooked food is the key to safety. You should:

  • Wash hands with warm water and soap for at least 20 seconds before and after handling raw

poultry and eggs;

  • Prevent cross-contamination by keeping raw poultry and eggs away from other foods;
  • After cutting raw meat, wash cutting board, knife, and countertops with hot, soapy water;
  • Use a food thermometer to ensure poultry has reached the safe internal temperature of at least

165 °F to kill foodborne germs that might be present, including the avian influenza viruses. Sanitize cutting boards by using a solution of 1 tablespoon chlorine bleach in 1 gallon of water.

Contact USDA Meat & Poultry Hotline with questions

Consumers with questions about the safe storage, handling, or preparation of meat,

poultry, and egg products, can call the USDA Meat & Poultry Hotline at: 1-888-MPHotline,

that’s 1-888-674-6854. The hotline is available in English and Spanish and can be reached from

10 a.m. to 4 p.m. (Eastern Time) Monday through Friday. Also, “Ask Karen” is the FSIS virtual

representative available 24 hours a day to answer your questions at www.fsis.usda.gov.

 

 

 

- Brooke Lounsbury

Medical Content Writer

Lifesaving Medications

Everyone should be empowered to care for themselves and their loved ones during the unexpected.

Recent Posts

Keeping you informed and safe.

How Long do My Meds Last? A Look at Metronidazole

How Long do My Meds Last? A Look at Metronidazole

What is metronidazole? Metronidazole is an antibiotic that is used to treat bacterial infections of the vagina, stomach, liver, skin, joints, brain and spinal cord, lungs, heart, or bloodstream. In 2020, it was the 222nd most commonly prescribed medication in the...

Pharmacy Techs Report Massive Drug Shortages

Pharmacy Techs Report Massive Drug Shortages

A highly concerning survey conducted by the Pharmacy Technician Certification Board, who grants a Supply Chain and Inventory Management for certification, has stated that nearly 96% of respondents report the pharmacy they work for faces drug shortages. Established in...

Bioterrorism at Our Door

The threat of deadly pandemics on US soil from our own Biolabs (either intentional or unintentional) is very real, and more commonplace than you would expect.

Biolab is a term used to refer to 4 levels of biosafety according to the pathogens researched in the labs. The more dangerous and infectious the agent the higher level of lab. For instance, a level 1 BSL has less restrictions on how pathogens are handled.

  • BSL-1 labs are used to study infectious agents or toxins not known to consistently cause disease in healthy adults. Handwashing and gloves and other minimal equipment are utilized in this level.
  • BSL-2 labs study moderate-risk infectious agents or toxins that pose a risk if accidentally inhaled, swallowed, or exposed to the skin.
  • BSL-3 laboratories are used to study infectious agents or toxins that may be transmitted through the air and cause potentially lethal infection through inhalation exposure.
  • BSL-4 laboratories are used to study infectious agents or toxins that pose a high risk of aerosol-transmitted laboratory infections and life-threatening disease for which no vaccine or therapy is available. An interactive map provided by by Schar School director of biodefense programs Gregory Koblentz and Filippa Lentzos of King’s College London   shows all the BSL4 level labs around the world.
  • Higher BSL levels can include multiple containment rooms, positive airflow suits, sealed rooms, etc.

The US government recently unveiled a report titled “National Biodefense Strategy and Implementation” focused on countering  the threat of accidental and intentional release of biological agents which result in pandemics. This is all well and good, however there are still  hundreds of accidents in these labs that are not widely reported to the general public, keeping us in the dark about the real and scary reality- that we are one accident away from a total depopulation scenario.

BSL labs around the world- the threat is real

The recent pandemic brought to light the real danger of laboratory accidents. A report released in October titled “An Analysis of the Origins of the COVID-19 Pandemic- an interim report” by the Senate Committee on Health Education, Labor and Pensions Minority Oversight Staff points to multiple biosafety failures at the WIV (Wuhan Institute of Virology). The report concluded that these biosafety failures led to the spread and pandemic of Covid-19, the report concluded.

Intercept, an independent journalism platform obtained documents through the Freedom of Information Act which revealed 18 years of laboratory accidents in biolabs across the United States. Intercept obtained over 5,500 pages of documents pointing to hundreds of accidents in labs. Most were in lower-level security labs, however there were quite a few disturbing numbers of accidents in the BSL3 and 4 labs. According to Intercepts findings these reports ranged from:

  • In 2010 an autoclave leaked steam and water while decontaminating waste from a SARS virus, potentially exposing eight people to the virus, which could spark a pandemic. Luckily ,the machine had already reached a high temperature — likely enough to kill the virus — before malfunctioning.
  • In 2011, a ferret that had been inoculated with the 1918 influenza strain- the strain that had killed an estimated 20-50 million people, bit a researcher, piercing the skin through his double gloved hands. The 1918 flu strain is housed in BSL3 level lab, and because is transmitted through respiratory droplets it is unlikely to cause the flu when bitten. The researcher cleansed the wound and was sent home to quarantine, not referred to a monitored room for isolation or a hospital. Given the deadly nature of the virus, some feel that even experimentation on this virus should be banned.
  • After pricking her finger with a needle, a graduate student at Washington University School of Medicine contracted the debilitating Chikungunya virus. This virus is housed in a BSL3 lab. She washed her hands and hadn’t told anyone of the needle prick until she became ill a few days later.
  • An internal audit on CBRNE exposure-the acronym for chemical, biological, radiological, nuclear, and high-yield explosives- revealed the army is ill equipped to handle emergencies of this type, citing lack of equipment and training. A pathogen, such as Anthrax, one of the most lethal bioweapons known could easily be spread due to personnel not receiving adequate training and lack of hazmat suits, respirators, etc.

The world is getting smaller every day. A virus believed to originate in China spread worldwide despite all the precautions and measures taken. It is just a matter of time before this scenario plays out again, affecting supply chains, overloading hospitals, water supplies , and more.

Be prepared. The JASE Case includes antibiotics effective against anthrax, tularemia, and other infectious agents. Please, this time around be prepared.

- Brooke Lounsbury

Medical Content Writer

Lifesaving Medications

Everyone should be empowered to care for themselves and their loved ones during the unexpected.

Recent Posts

Keeping you informed and safe.

How Long do My Meds Last? A Look at Metronidazole

How Long do My Meds Last? A Look at Metronidazole

What is metronidazole? Metronidazole is an antibiotic that is used to treat bacterial infections of the vagina, stomach, liver, skin, joints, brain and spinal cord, lungs, heart, or bloodstream. In 2020, it was the 222nd most commonly prescribed medication in the...

Pharmacy Techs Report Massive Drug Shortages

Pharmacy Techs Report Massive Drug Shortages

A highly concerning survey conducted by the Pharmacy Technician Certification Board, who grants a Supply Chain and Inventory Management for certification, has stated that nearly 96% of respondents report the pharmacy they work for faces drug shortages. Established in...

Prepared Equals Peace of Mind

Prepared equals peace of mind

What is labeled “prepping” or being a “prepper” used to be how everyone lived as recent as 50 years
ago. Our just- in- time supply chains weren’t around back then. Amazon, and online shopping didn’t
exist. Back then, if you wanted something you had to either call the company and place an order or mail
a check in.

The Sears catalog, along with many other catalogs would arrive and you and your family would spend
hours poring over the pages. These pages were filled with almost anything you may need or want, from
bed sheets to tools for the shop. In essence, those catalogs were the modern-day equivalent of Amazon.
Sometimes it would take a month or so for the much-awaited order to arrive. This was normal. Back
then, if you wanted something you had to plan for it.

Just in time supply chain

Fast forward to today. With all the wonderful technology, the same day deliveries, and almost any item
at our disposal within a few days, we have become complacent. Don’t get me wrong, we have used this
system to receive much needed items, in some cases almost immediately. This is the wonder of our
technological age. But it comes at a price. We take for granted that these supply chains will always be
running smoothly. Our world economy, for the past several decades has made life more convenient and
opened our lives to new experiences and time saving devices.
Technology- double edged sword

Our global world is a double-edged sword. The convenience we so much rely on, can and has been in the
process of failing over the past few years. The consequences to our healthcare system have been
devastating. Medical supplies such as contrast dye and drugs, have been in short supply or altogether
unavailable with no end in sight. This illustrates how fragile our medical system is. We are only one
natural or manmade disaster, pandemic, political or civil unrest from the complete shutdown of life
saving drugs and medical supplies.

Pharmaceuticals outsourced

The last major pharmaceutical manufacturing operation closed its doors and left the United States in
2004. Since then, nearly all the active ingredients for antibiotics and chronic medications – even
vitamins – are produced overseas, mainly in China and India.
Take, for instance the current amoxicillin shortage.

Across the country many pharmacies have reported a limited or not available supply of amoxicillin.
Amoxicillin is one of the first antibiotics used to treat strep throat, ear infections, urinary tract infections
and many other infections. The shortage includes amoxicillin in pill form, powder to mix with water to
make a suspension, and chewable tablets.

The American Society of Healthcare Pharmacists maintains a database of drug shortages and
manufacturers. They have listed amoxicillin manufacturers who have reported shortages or no
availability.

• Aurobindo, with facilities located throughout the world, refuses to provide availability
information.
• Hikma, based out of the UK, did not provide a reason for the shortage.
• Rising, based out of New Jersey has amoxicillin capsules and tablets available, but doesn’t state
whether they have amoxicillin powder available
• Sandoz, headquartered in Switzerland did not provide a reason for the shortage.
• Teva, which is based out of Israel did not provide a reason for the shortage.

However, the FDA states the only shortage is amoxicillin in powder form. This is because if even one
manufacturer can supply the necessary drug there is no perceived shortage.

This is very disturbing. All it takes is that one manufacturer to declare either a shortage or the drug
not available at all and the US supply is dried up.

Augmentin, (amoxicillin / clavulanate) is one of the antibiotics included in the Jase Case (see below how
to order a Jase Case). This can be substituted for amoxicillin if amoxicillin isn’t available.

Generics less likely to be manufactured

An analysis conducted by the US Pharmacopeia, a group that sets standards around the world for
medicines, found that antibiotics are 42% more likely to be in shortage in the US compared to other
types of drugs. Most antibiotics are now generic.

According to an analysis by the FDA Report “Drug Shortages: Root Causes and Potential Solutions”
identified three root causes of drug shortages.

1. Lack of incentives for manufacturers to produce less profitable drugs. (Generics aren’t very
profitable)
2. The market does not recognize and reward manufacturers for “mature quality systems” that
focus on continuous improvement and early detection of supply chain issues; and
3. Logistical and regulatory challenges make it difficult for the market to recover from a disruption.
The fragile global supply chains mean that if a pharmaceutical factory is down in China, you may not be
able to find your prescription at the neighborhood pharmacy. Lifesaving antibiotics are at risk of running
out faster than any other medicine. Medicines that are now available could easily run out. This could
lead to dire consequences.

Jase Medical is on a mission

JASE Medical is a telemedicine company with a singular focus to change all of that. This platform offers
access to basic emergency preparedness medications for every family in America.

And how will they do that? Well, it won’t happen overnight. But JASE Medical has done its homework
and established a nationwide network of physicians trained to evaluate individual needs, assess
conditions, and prescribe appropriate prescriptions for emergency preparedness purposes. From there,
licensed pharmacists fill your prescription, and the Jase Case is sent to your home.

These are the medications that will become lifesaving for you and the people you care about. And it’s all
done online through the JASE Medical portal.

How it works

When you log on to the platform and begin your consultation, you will find a simple and user-friendly
experience. The consultation takes little over five minutes to complete. After a licensed Jase healthcare
provider has reviewed your health history and any allergic reactions to medications, your prescriptions
are filled, and your Jase Case is shipped to your front door.

What’s in the JASE Case?
The kit contains the following antibiotic medications:
 Amoxicillin/Clavulanate.
 Azithromycin.
 Ciprofloxacin.
 Doxycycline.
 Metronidazole.
(Substitutions are made if allergic to one of the antibiotics)

All medications carry a level of risk, but these five antibiotics were selected for their effectiveness and
optimal patient safety. Guidance from the CDC says it best: “Antibiotics … save lives, and when a patient
needs antibiotics, the benefits usually outweigh the risks of side effects and antibiotic resistance.”

Some of the infections a Jase Case can treat
 Anthrax, plague and tularemia (resulting from bioterror).
 Bite wounds.
 Cellulitis.
 Diverticulitis.
 Intra-abdominal infections.
 Tooth infections.
 Ear infections.
 Pneumonia.
 Sinusitis.
 Strep throat.
 Urinary tract infection.
 and more.

When access to your healthcare provider isn’t possible (you are on vacation, etc.) your Jase case
includes a symptom and antibiotic use handbook titled the “Emergency Antibiotic Guide “with easy-to-
follow instructions to ensure proper use of the antibiotics if indicated.
What about chronic conditions?

Soon, the JASE Medical platform will provide emergency preparedness medicines for those with chronic
medical conditions (such as blood pressure and other chronic conditions). JASE Medical’s same
physician network will assess your condition and the need for appropriate preparedness medicines.

Ongoing support

As part of its mission to prepare you medically, JASE Medical provides unlimited ongoing support from
their physician network for questions about any of the medications prescribed.

What about shelf life?

The good news about antibiotics is that they last longer than you think. The FDA’s Shelf-Life Extension
Program found that 88% of the drugs studied maintained their potency and safety beyond the published
expiration date. The extended usability of these medications ranged from 5.5 years to as many as 23
years beyond their printed expiration!

The JASE Case antibiotics all carry the FDA’s required expiration dates. JASE Medical endorses those
dates.

Value and peace of mind

At the end of the day, this is all about peace of mind and knowing that you are ready for the
unexpected. Knowing that you have found a solution, priced at a fraction of what it would otherwise
cost you, adds to that peace of mind.

Go to JaseMedical.com and secure your emergency medications, an emergency antibiotic guide,
unlimited physician consultation and a team of professionals who are on a mission to keep you and your
loved ones prepared and safe during these uncertain times.

- Brooke Lounsbury

Medical Content Writer

Lifesaving Medications

Everyone should be empowered to care for themselves and their loved ones during the unexpected.

Recent Posts

Keeping you informed and safe.

How Long do My Meds Last? A Look at Metronidazole

How Long do My Meds Last? A Look at Metronidazole

What is metronidazole? Metronidazole is an antibiotic that is used to treat bacterial infections of the vagina, stomach, liver, skin, joints, brain and spinal cord, lungs, heart, or bloodstream. In 2020, it was the 222nd most commonly prescribed medication in the...

Pharmacy Techs Report Massive Drug Shortages

Pharmacy Techs Report Massive Drug Shortages

A highly concerning survey conducted by the Pharmacy Technician Certification Board, who grants a Supply Chain and Inventory Management for certification, has stated that nearly 96% of respondents report the pharmacy they work for faces drug shortages. Established in...

Powered by